HIPEC (Hyperthermic Intraperitoneal Chemotherapy)

HIPEC (Hyperthermic Intraperitoneal Chemotherapy)

A technique combining complete surgery of peritoneal lesions with heated chemotherapy delivered into the abdomen during the same operation.

What is it?

HIPEC (hyperthermic intraperitoneal chemotherapy) is a specialised technique intended for certain cancers that have reached the peritoneum, the membrane lining the inside of the abdomen. It combines two complementary stages within a single operation: complete surgical removal of the visible lesions, followed by the delivery of heated chemotherapy directly into the abdominal cavity. Heat increases the effectiveness of the chemotherapy, and its local delivery makes it possible to reach microscopic residual cells while limiting its spread to the rest of the body. This demanding approach is intended for patients rigorously selected at a multidisciplinary team meeting, after a very thorough work-up. At Clinique Pasteur Tunis, HIPEC is performed by a trained surgical and anaesthetic team, with post-operative monitoring in intensive care. The patient and their family are informed at length beforehand about the course of the operation and the convalescence, which takes time and requires ongoing support.
HIPEC (Hyperthermic Intraperitoneal Chemotherapy)

When is it indicated?

Peritoneal involvement of certain digestive cancers, in selected cases

When a digestive cancer has reached the membrane lining the abdomen, HIPEC offers well-selected patients a treatment option where possibilities used to be limited.

Certain ovarian tumours with peritoneal spread

Some ovarian cancers spread to the peritoneum: combining complete surgery with heated chemotherapy can then strengthen the treatment.

Pseudomyxoma peritonei

This rare disease, in which a jelly-like substance accumulates in the abdomen, finds its reference treatment in HIPEC.

Peritoneal mesothelioma, after specialist advice

This rare tumour of the abdominal membrane can benefit from HIPEC in certain situations, always after the advice of a specialised team.

Indication always validated at a multidisciplinary team meeting

HIPEC is a demanding operation: the decision is always made collectively by the surgeons, oncologists and radiologists, in the patient's best interest.

Preparation

1Exhaustive work-up: complete imaging and precise assessment of the extent of the lesions
2Assessment of the patient's general and nutritional condition
3Validation of the indication at a multidisciplinary team meeting
4In-depth anaesthesia consultation
5Detailed information for the patient and their family about the operation and the convalescence

Procedure

1

General anaesthesia with enhanced monitoring

2

Complete exploration of the abdominal cavity

3

Surgical removal of all visible peritoneal lesions

4

Setting up of the intraperitoneal perfusion circuit

5

Delivery of the heated chemotherapy into the abdomen for the required time

6

Washing, checks and closure

7

Transfer to intensive care for initial monitoring

Duration

A long operation, often 6 to 10 hours

Aftercare & Recovery

Convalescence is gradual, with an initial stay in intensive care followed by an extended hospital stay while digestive and nutritional recovery takes place. Close oncological follow-up is then organised. For well-selected indications, HIPEC offers a treatment option where possibilities used to be limited.

Risks and side effects

Digestive complications (leak, delayed return of bowel function), closely monitored post-operatively
Temporary effects of the chemotherapy on blood tests, checked regularly
Post-operative infections, prevented and actively treated
Extended convalescence requiring nutritional support

These risks remain rare. Your surgeon will inform you in detail before the procedure.

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At a glance

Duration: A long operation, often 6 to 10 hours
Preparation: Required
Dedicated specialist team