HIPEC (Hyperthermic Intraperitoneal Chemotherapy)

HIPEC (Hyperthermic Intraperitoneal Chemotherapy)

An innovative treatment combining complete surgery of peritoneal lesions with heated chemotherapy delivered directly into the abdomen.

What is it?

HIPEC, or Hyperthermic Intraperitoneal Chemotherapy, is an innovative treatment for tumour involvement of the peritoneum, the thin membrane that lines the inside of the abdomen and envelops the digestive organs. It combines two complementary stages within a single operation. The first stage is surgical: the surgeon removes as completely as possible all visible lesions of the peritoneum, a procedure called cytoreduction. The second stage consists of circulating heated chemotherapy in the abdominal cavity for a set period: the heat enhances the effectiveness of the treatment, which acts in direct contact with the areas to be treated while limiting diffusion to the rest of the body. This combined approach is intended for selected cases of peritoneal involvement, after an in-depth work-up and validation in a multidisciplinary consultation meeting. It represents one of the most advanced treatments in abdominal oncological surgery and requires a specifically trained team. At Clinique Pasteur Tunis, HIPEC is performed by a team well versed in major digestive surgery, in a highly secure environment, with post-operative monitoring in intensive care and personalised support for the patient throughout the pathway.
HIPEC (Hyperthermic Intraperitoneal Chemotherapy)

When is it indicated?

Selected peritoneal involvement of colorectal origin

When a cancer of the colon or rectum has reached the membrane lining the abdomen, HIPEC can offer, in carefully selected patients, a genuine prospect of treatment.

Pseudomyxoma peritonei

For this rare disease in which a gelatinous substance progressively invades the abdomen, HIPEC is the recognised reference treatment.

Certain peritoneal involvement of ovarian or gastric origin

Extensions to the peritoneum of cancers of the ovary or stomach can, in specific situations, benefit from this combined approach of surgery and heated chemotherapy.

Rare tumours of the peritoneum, after multidisciplinary validation

Each rare situation is studied collectively by the specialists involved before HIPEC is proposed, to guarantee that the treatment will bring a real benefit.

Preparation

1Complete imaging work-up assessing the extent of peritoneal involvement
2Validation of the indication in a multidisciplinary consultation meeting
3Nutritional assessment and optimisation of general condition
4In-depth anaesthesia consultation
5Fast for 6 hours before the procedure

Procedure

1

General anaesthesia with advanced monitoring

2

Complete exploration of the abdominal cavity

3

Cytoreduction: removal of all visible peritoneal lesions

4

Circulation of heated chemotherapy in the abdomen for the duration set by protocol

5

Rinsing, final checks and closure

6

Transfer to intensive care for close monitoring

Duration

6 to 10 hours depending on the extent of the lesions

Aftercare & Recovery

Recovery takes place first in intensive care, then on the ward with a very gradual return to eating. Convalescence extends over several weeks, with nutritional support and regular oncological follow-up. In the selected indications, this treatment offers significantly improved prospects.

Risks and side effects

Long, specialised operation, reserved for carefully selected indications
Post-operative course closely monitored in intensive care
Prolonged fatigue requiring supported convalescence

These risks remain rare. Your surgeon will inform you in detail before the procedure.

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At a glance

Duration: 6 to 10 hours depending on the extent of the lesions
Preparation: Required
Dedicated specialist team